Behavioral mechanism of human sperm in thermotaxis: a role for hyperactivation
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چکیده
منابع مشابه
Behavioral mechanism of human sperm in thermotaxis: a role for hyperactivation.
STUDY QUESTION What is the behavioral mechanism underlying the response of human spermatozoa to a temperature gradient in thermotaxis? SUMMARY ANSWER Human spermatozoa swim up a temperature gradient by modulating their speed and frequencies of hyperactivation events and turns. WHAT IS KNOWN ALREADY Capacitated human spermatozoa are capable of thermotactically responding to a temperature gra...
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When mammalian spermatozoa become capacitated they acquire, among other activities, chemotactic responsiveness and the ability to exhibit occasional events of hyperactivated motility--a vigorous motility type with large amplitudes of head displacement. Although a number of roles have been proposed for this type of motility, its function is still obscure. Here we provide evidence suggesting that...
متن کاملControl of hyperactivation in sperm.
BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus. Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending. ...
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A unique characteristic of mammalian sperm thermotaxis is extreme temperature sensitivity, manifested by the capacity of spermatozoa to respond to temperature changes of <0.0006 °C as they swim their body-length distance. The identity of the sensing system that confers this exceptional sensitivity on spermatozoa is not known. Here we show that the temperature-sensing system of mammalian spermat...
متن کاملThe mechanics of hyperactivation in adhered human sperm
Hyperactivation is an important phenomenon exhibited by mammalian sperm during the process of acquiring fertilization capacity. The majority of studies have focused on incubation-induced hyperactivation in non-human species, which typically differ in size, shape, and are more homogeneous than human sperm. We develop an alternative approach via drug-induction, using high-speed imaging and analys...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2015
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/dev002